Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties, such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective.Two coumarin-based products we
Effective generation of transgenic pigs and mice by linker based sperm-mediated gene transfer.
Abstract Background Transgenic animals have become valuable tools for both research and applied purposes.The current method of gene transfer, microinjection, which is widely used in transgenic mouse production, has only had limited success in producing transgenic Horse Water Repellents animals of larger or higher species.Here, we report a linker ba
THE JAK2V617F POINT MUTATION INCREASES THE OSTEOCLAST FORMING ABILITY OF MONOCYTES IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS AND MAKES THEIR OSTEOCLASTS MORE SUSCEPTIBLE TO JAK2 INHIBITION
JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level.We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients.We studied 18 newly diagnosed MPN patients and four age-matched normal donors (ND).Osteoclast formin
No Need for Templates in the Auditory Enhancement Effect.
The audibility of a target tone in a multitone background masker is enhanced by the presentation of a precursor sound consisting of the masker alone.There is evidence that precursor-induced neural adaptation plays a role in this perceptual enhancement.However, the precursor may also be strategically used by listeners as a spectral template of the f
The emotional labour of higher education teachers : a scoping review
The role of higher education teachers (HETs) encompasses a multitude of responsibilities and requires continual professional development to meet job demands.Yet, these HETs encounter challenging conditions within work environments, which can adversely impact their performance as well as their physical and mental health.Moreover, the nature of teach