THE JAK2V617F POINT MUTATION INCREASES THE OSTEOCLAST FORMING ABILITY OF MONOCYTES IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS AND MAKES THEIR OSTEOCLASTS MORE SUSCEPTIBLE TO JAK2 INHIBITION

JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level.We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients.We studied 18 newly diagnosed MPN patients and four age-matched normal donors (ND).Osteoclast formin

read more

No Need for Templates in the Auditory Enhancement Effect.

The audibility of a target tone in a multitone background masker is enhanced by the presentation of a precursor sound consisting of the masker alone.There is evidence that precursor-induced neural adaptation plays a role in this perceptual enhancement.However, the precursor may also be strategically used by listeners as a spectral template of the f

read more